However, type strain of this species has not been genome-sequenced yet. aureus were genome-sequenced and submitted to public databases due to the importance in antibiotic resistance and the possibility of nosocomial infections even in health care and community settings. aureus was detected in irritable bowel syndrome (IBS) subjects. aureus with symptoms such as diarrhea, nausea and abdominal cramps. Foodborne illness can be caused by enterotoxin-producing S. The species can spread through skin-to-skin contact with colonized individuals, and cause a global epidemic as antibiotic resistant strains. S aureus was also reported as the predominant species in infant feces, and decreased toward adulthood due to the colonization of complex gut microbiota. This species can cause a broad range of nosocomial and community-associated infections, and the antibiotic resistance of the species has been studied for many years. Staphylococcus aureus is a member of normal microbiota in human body and also known as an opportunistic pathogen. Further comparative genomic studies of methicillin-resistant strains based on this reference genome would help to understand the evolution of resistance mechanism and dissemination of resistance genes. Methicillin resistance genes found in the genome indicate the presence of antibiotic resistance mechanism prior to the usage of antibiotics. aureus type strain as the reference sequence for comparative genomic analyses of clinical isolates. The present study analyzed the genome sequence of S. It is interesting to note that this strain was first isolated in 1884 before methicillin was generally used on patients. Among the 2,550 annotated CDSs, 44 CDSs were annotated to antibiotic resistance genes and 13 CDSs were related to methicillin resistance.
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The length of the genome sequence was 2,902,619 bases with a G + C content of 32.8%. Seventeen contigs were generated using hybrid assembly of sequences derived from the Roche 454 and Illumina systems. To extend our understanding of the species and use the genome data for comparative genomic studies, we sequenced the type strain of S. The relatively small genome size and rapid evolution of antibiotic resistance genes in the species have been drawing an increasing attention in public health. This species is an indigenous intestinal microbe found in infants and not found in adult intestine.
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Staphylococcus aureus is a pathogen that causes food poisoning and community-associated infection with antibiotic resistance.